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doi: 10.1155/2019/7247238, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 17
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IL-2 was first investigated as a plasmid-encoded adjuvant in 2005, when it was shown murine IL-2 fused to Ig (IL-2/Ig) co-administered with a DNA vaccine encoding HIV-1 env gp120 in mice, significantly enhanced both antibody and cell-mediated immune responses compared to the DNA vaccine alone (92)
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