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Definition and classification of cancer cachexia: An international consensus

159 A 2010 trial in 17 pancreatic cancer patients showed that 8,000 mg of curcumin daily, in conjunction with gemcitabine, was often not well tolerated and led to curcumin discontinuation due to abdominal complaints in 29% of subjects

doi: 10.1139/y89-114

The resulting downregulation of TLR4/NF-B/NLRP3 signaling led to suppressed cytokine storms and enhanced organ protection in septic mice (Zhao et al., 2025)
