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High doses of vitamin B6 can lessen the effect of Parkinsons medicines that contain levodopa without carbidopa

Richard-Carpentier G, Jabbour E, Short NJ, Rausch CR, Savoy JM, Bose P, Yilmaz M, Jain N, Borthakur G , Ohanian M, Alvarado Y, Rytting M, Kebriaei P, Konopleva M, Kantarjian H, Ravandi F

Adolescents aged 1114 years require 1.2 mcg per day , reflecting increased demands during puberty and rapid growth

3c) and confirmed that Efmody improved the biochemical control of CAH by reducing the excess morning 17OHP, from 31% of patients in control at the beginning of the study to 94% after 6 months on Efmody treatment