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However, our findings indicated that Cu alone was insufficient to effectively activate IFNB1 expression in vitro , probably due to the limited capacity of low Cu concentrations to significantly elevate ROS levels

Norton, K.-A., Gong, C., Jamalian, S

However, taking glutathione orally might not be as effective as another method of ingesting it because, when taken orally, the substance passes through your digestive tract, where digestive enzymes get to work, potentially dissolving your glutathione supplement

There is evidence here