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Extracellular Matrix and Collagen Studies GHK-Cu is frequently used in studies involving collagen production, fibroblast activity, and extracellular matrix remodeling

RSC Med

it is naturally occurring, nontoxic, and is active at a very low nanomolar concentration.11 Another piece of research described GHK-Cu as a safe, inexpensive, extensively studied compound.3 These conclusions primarily apply to topical GHK-Cu, but even with injectables, the lack of serious adverse events in animal subjects points to a general tolerability regardless of the route of administration

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