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With its pyrophosphate serving as an anchor at the water-membrane interface, the C 55 isoprenoid is modeled to sample a large conformational space within the hydrophobic core of the membrane by acquiring extended and bent conformations
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Like freckles, the distribution of solar lentigines is limited to sun-exposed areas, particularly sites of greatest cumulative exposure such as the face, dorsal aspect of the hands, extensor forearms, and upper trunk
