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Abbreviations AIH: autoimmune hepatitis ALP: alkaline phosphatase ALT: alanine aminotransferase AMA: antimitochondrial antibody ANA: antinuclear antibody ASMA: anti-smooth muscle antibody AST: aspartate aminotransferase Bili: bilirubin DILI: drug-induced liver injury HMG-CoA: hydroxymethyl glutaryl coenzyme A reductase HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase IAHG: International Autoimmune Hepatitis Group RUCAM: Roussel Uclaf Causality Assessment Method ULN: upper limit of normal Declarations Acknowledgement This work was made possible by the Herman Lopata Chair in Hepatitis Research
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purification from calf-liver mitochondria and some properties of the enzyme
