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Besides conventional drug discovery approaches, cost-effective ways to accelerate identification of novel antimalarial strategies have included (i) combination therapy, by joining two or more known drugs, (ii) covalent bitherapy, by conjugating different pharmacophores, (iii) repurposing of drugs with other therapeutic indications, and (v) rescuing of known antimalarial scaffolds

Matsuki, H

H., Steullet P., Morishita H., et al

For sure, standard redox potentials, with appropriate consideration of pH, temperature, and concentration effects, can tell us in which direction a reaction between different redox couples might go