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Description
Theoretical and reported concerns Off-target cell death: no compound is perfectly selective, so healthy cells with temporarily high FOXO4 could be affected in theory
However, these same protective mechanisms create a major pharmacological bottleneck, particularly for biologics such as antibodies, enzymes, and nucleic acid-based therapeutics exceeding 400-500 Da
LQ: data curation, formal analysis, project administration, and writingreview and editing
Experimental & Molecular Medicine
