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Acetyl-L-carnitine was successfully applied as pharmacological agents for treatment of chronic degenerative diseases of the senile brain and for slowing down the progression of mental deterioration in Alzheimer's disease, and they may involve both the cholinergic neuronal transmission activity of acetyl-L-carnitine and its ability to enhance neuronal metabolism in mitochondria. Older men and women who took ALCAR daily saw a significant boost to their physical and mental energy levels, as well as better overall cognitive ability

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However, one study demonstrated that treatment with acetyl-L-Carnitine restored the expression and activity of SIRT3, consequently improving mitochondrial function [74]

doi: 10.1038/ncb2152 59 ChanEYKirSToozeSA