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Chronic non-specific inflammation is pivotal in tumorigenesis (122) and is a primary environmental factor contributing to the onset and metastasis of specific types of cancer such as non-small cell lung cancer and colorectal cancer (122,123)

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Although this definition has been employed for many years, the definition of oxidative stress has recently been modified to account for two different mechanistic outcomes of oxidative conditions

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis