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En este tipo de lesiones, el calcio depositado en los tejidos acta como una autntica piedra irritante que mantiene la inflamacin crnica y el dolor
Paulos CM, Turk MJ, Breur GJ, Low PS

As a single agent in phase 2 dose-finding, cagrilintide produced dose-dependent weight loss of roughly 1011% at the highest dose over 26 weeks [4]

Laminin-5 and MMP upregulation TB4 induces expression of matrix metalloproteinases (MMP-2, MMP-9) that remodel extracellular matrix during healing (Malinda 1999 J Invest Dermatol)
