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The R radicals reaction with O 2 yielding ROO

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DOI: 10.1016/j.jtumed.2018.04.007 39

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Moreover, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated Na + /Cl influx further disturbs osmotic balance, contributing to cytotoxic edema, a process blocked by AMPA antagonists (e.g., perampanel) in rodent models [139, 140]

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