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Similarly, the tumor suppressor protein p53, known for its multifaceted roles in maintaining genomic stability and orchestrating cellular stress responses, exerts intricate control over glutamine metabolism [32]

and reducing serum blood urea nitrogen (BUN) and creatinine levels [51]

Another study indicated that a ketogenic diet, which results in elevated levels of ketones (e.g., -hydroxybutyrate) in the blood, could prevent sleep deprivation-induced Alzheimers disease (AD) by inhibiting ferroptosis, and lipid peroxidation, and improving the neuronal repair ability via SIRT1/NRF2 signaling pathway (Yang et al

methylphenidate being more effective for 'executive function')