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SCFAs exert their effects primarily by activating G protein-coupled receptors, including free fatty acid receptor 2 (FFAR2/GPR43) and free fatty acid receptor 3 (FFAR3/GPR41), which enhances the secretion of gut hormones like GLP-1 and peptide YY (PYY) to improve insulin sensitivity and modulate HPG axis function

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Ensemble-based signatures of energy propagation in proteins: a new view of an old phenomenon