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Currently, two main theories are widely accepted, including the trigeminovascular system (TGVS) theory and the cortical spreading depression (CSD) theory

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Introduction Triple-negative breast cancer (TNBC) is a heterogeneous group of breast cancers, characterized by lack of expression of estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 gene amplification, making it unresponsive to endocrine therapy and HER2-targeted treatment

Journal Impact Factor = 4.525, Times Cited = 10 (ResearchGate) Bruni, Natascia, et al