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Emerging evidence indicates that probiotics, by influencing the gut microbiota, may play a role in regulating skeletal muscle metabolism through potential mechanisms including inflammation modulation, shortchain fatty acid (SCFA) production, insulin sensitivity, muscle protein synthesis, and hormonal regulation (Okubo et al

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More importantly, after long-term CCl4 treatment in Nrf2 gene knockout mice, liver fibrosis was severely intensified, and inflammation increased (Xu et al., 2008)