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To ensure the adaptive metabolic responses of cells in hypoxia, this mechanism required the HIF-1-dependent expression of BNIP3 and constitutive expression of Beclin-1 and Atg5, which lowered mitochondrial numbers and prevented a increase in ROS [29]
10.2147/IJN.S144452 79 HuoS.WangQ.ShiW.PengL.JiangY.ZhuM.et al (2023)

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