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They also have harmful effects on embryo development (Pietrzik and Bronstrup, 1997
IGF-1 Receptor Signaling Research has examined IGF-DESs interactions with the IGF-1 receptor (IGF-1R) and subsequent downstream signaling cascades

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(2) Gut microbiota divergence The place of birth significantly influences an individual's gut microbiome, rather than the human species itself
