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Description
Systemic drugs Sorafenib, the first tyrosine kinase inhibitor authorized for the treatment of patients with unresectable HCC, advanced renal cell carcinoma, and differentiated thyroid cancer, 210 has been shown to trigger ferroptosis by inhibiting system xc- and increasing intracellular iron levels

Hashimoto thyroiditis: clinical and diagnostic criteria
doi: 10.1006/geno.1996.4493

With time, macrophages can shift toward an M2 phenotype, producing TGF- and PDGF that promote fibroblast activation and ECM deposition, driving late fibrosis
