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finally, in terms of limitations, it highlights the heterogeneity in evidence [e.g., variations in Omega-3 dosing across RCTs (65)] and population-specific biases [e.g., vitamin D studies focusing on IBD patients (169)]

doi: 10.1186/s13148-020-00874-w 78 YangZWangTWuDMinZTanJYuBet al

coli using its type VI secretion system to successfully establish itself within the murine gut (145)
Dismissing such studies in favor of lower-quality evidence with greater potential for bias represents a fundamental rejection of evidence-based principles (Guyatt et al., 2008[47]
