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Description
Tissue Specificity and Metabolic Effects Importantly, these metabolic effects appear to be tissue-specific to adipose tissue, as studies have not shown similar effects on muscle protein metabolism or bone growth

You can also have a BMI of at least 27 if you also have a weight-related health condition, such as high blood pressure, cardiovascular disease, or obstructive sleep apnoea

doi:10.1016/S0076-6879(71)18006-8

Human data is early but promising
