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18(2):185 Multifunctionality and possible medical application of the BPC 157 peptide: literature and patent review Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D., International Immunopharmacology , 2023

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Mechanistically, HGF inhibits inflammatory M1-like macrophage production of pro-inflammatory cytokines and chemokines (such as IL-1, IL-6, TNF, CXCL1, CXCL10, and CCL2) by disrupting nuclear factor NF-B signaling (Giannopoulou et al., 2008) through the enhancement of the heme oxygenase-1 (HO-1) transcriptional pathway and the inactivation of the GSK-3 pathway (Kamimoto et al., 2009a,b