glutathione peroxidase hepatic 1 deficiency attenuates concanavalin A-induced injury by modulation of T-cell activation The glutathione peroxidase family: Discoveries

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In Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology vol

"Late-onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbance"

Normally, the transcription factor Nrf2 and its inhibitory protein KEAP1 are tightly bound to inhibit activity, but in the presence of ROS, a conformational change in KEAP1 results in the release of NRF2, which binds to the antioxidant response element (ARE) and activates the downstream genes heme oxygenase-1 (HO-1), glutathione peroxidase 4 (GPX4), quinone oxidoreductase1(NQO1), thioredoxin reductase 1 (SRXN1), and transcription of solute carrier family 7 member 11 (SLC7A11), which enhance cellular antioxidant defenses and inhibit ferroptosis (Wang et al., 2022