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Quality control (QC) samples were included to check the technical variability and were prepared by mixing an equal volume of lipid extract from each tissue or serum sample

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Grape seed extract appears to protect the ileal epithelium in IL10KO mice by inhibiting inflammatory responses (e.g., downregulating the NF-B pathway) and modulating autophagy (e.g., downregulating the AMPKBeclin-1 pathway), thereby restoring normal proliferation and differentiation of epithelial cells (Yang et al., 2014)

Despite methodological constraints, the study highlights the urgent need for clinically validated pharmacogenomic testing to personalize antidepressant dosing, mitigate adverse reactions, and optimize therapeutic efficacy across diverse populations