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SALL4 deletions are a common cause of Okihiro and acro-renal-ocular syndromes and confirm haploinsufficiency as the pathogenic mechanism

Advanced / Aggressive Approach (3 mL = ~6,667 mcg/mL) Advanced daily dose: 500 mcg total blend once daily ~8 units on a 20 mg vial, ~15 units on a 10 mg vial

Neurological damage can occur without anaemia and may become irreversible if deficiency remains untreated for prolonged periods
