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Hypoxia promotes GSH synthesis in seal cells High tissue and circulating GSH levels, as well as high activity of many glutathione-dependent antioxidant enzymes, including glutathione peroxidases (GPX) and glutathione S -transferases (GST) [18, 20,21,22, 63], suggest a critical role for GSH in protecting diving mammals against oxidative stress

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Oxidation-specific epitopes such as MDA are molecules known to have extremely proinflammatory properties, being correlated to depression by interacting with pathways such as tryptophan/kynurenine