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Studies on mice models showed that a high-fat diet correlates with decreased GLP-1 production, reduced GLP-1 receptor sensitivity, impaired ghrelin secretion, and sensitivity, thus determining a diet-induced low-grade organ-specific and systemic inflammation [28]
D.RuizP.EichnerJ
JCI Insight (2022) 7(2):e152611
Its modified D-isomer structure is designed to enhance stability and resistance to enzymatic degradation , allowing researchers to investigate FOXO4-related pathways over extended experimental timeframes in controlled laboratory environments
