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The dual blockade of MET and VEGFR2 signaling demonstrates pronounced inhibition on tumor growth and metastasis of hepatocellular carcinoma

Detailed biophysical studies (X-ray crystallography, EPR, NMR) elucidated that in GHK-Cu, the Cu(II) ion is coordinated by the imidazole side chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the glycine-histidine bond

NF-B translocates to the nucleus to drive expression of pro-inflammatory genes such as TNF- (49)