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Providers must ensure that documentation justifies not only the drug administration but also the absence of an alternative HCPCS code, since payers frequently deny J7999 when a more specific code should have been reported

Ketamine was initially introduced as an anesthetic and analgesic for medical applications ( 5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission ( In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function

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[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Cardoso A.L., Fernandes A., Aguilar-Pimentel J.A., De Angelis M.H., Guedes J.R., Brito M.A., Ortolano S., Pani G., Athanasopoulou S., Gonos E.S., et al
