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EVIDENCE GRADES 12-week Metabolic Pharmaceuticals Phase 2b at 1 mg/day did not meet primary weight-loss endpoint

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Nausea affects approximately 44% of participants in pooled STEP trial data, with diarrhea (30%), vomiting (24%), and constipation (24%) also common

Section 1895(b)(3)(D)(i) of the Act requires the Secretary annually to determine the impact of differences between assumed behavior changes, as described in section 1895(b)(3)(A)(iv) of the Act, and actual behavior changes on estimated aggregate expenditures under the HH PPS with respect to years beginning with 2020 and ending with 2026
