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Increased ROS production promotes viral establishment during acute infections, whereas Nrf2 activation may be beneficial to the virus by increasing the host cells ability to cope with the oxidative stress resulting from viral infection and/or inflammation

10.3389/fncel.2015.00501 Front

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The carbohydrate moieties on viral S-protein surface could facilitate viral internalization via innate immune factors, such as neuropilin (NRP)-1, C-lectin type receptors (CLR), and toll-like receptors (TLR), as well as the non-immune receptor glucose-regulated protein 78 (GRP78) for systemic spread of infection 61