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however, no definitive clinical consensus has established the clear superiority of one source over another, underscoring the need for head-to-head comparative trials [95, 96]

Indeed, pharmacological inhibition of xCT increases reactive oxygen species (ROS) level and suppresses tumor growth [54,55]

A study conducted by the Panel on Dietetic Products for the European Food Safety Authority in 2017 concluded that ergothioneine is safe for children above 3 years of age and the general adult population, including pregnant and breastfeeding women

This possibility is substantiated by the occurrence of hyperhomocysteinemia in humans exhibiting cystathionine -synthase deficiency [67, 68]