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these are chemosensors expressed primarily in a region-specific way in gastric and stomach ghrelin cells, and their function is to modulate gastrointestinal responses to food intake, for example by inhibiting ghrelin secretion ( Ghrelin and Pituitary GH Secretion Ghrelin stimulates GH release in the pituitary by acting at two levels: 1) directly on the pituitary somatotrophs and 2) antagonizing the hypothalamic and pituitary effects of SS and inducing GHRH secretion