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[0551] Additional promoter elements, e.g., enhancers, regulate the frequency of transcriptional initiation

demonstrated that the intravitreal injection of synthetic melanin-like nanoparticles can clear free radicals, with reduced ROS production in RPE cells, finally alleviate the vascular leakage and show the anti-angiogenic activity in an AMD-like model

Therefore, the synthesis of the primary low-molecular cellular antioxidant glutathione is interdependently linked to the folate pathway, thus any aberrant disruptions in folate metabolism can result in potentially deleterious effects as a result of an imbalance in the cellular redox state