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104 Fatty acid synthase and acetyl-CoA carboxylase 1, which are two key enzymes that are involved in hepatic lipogenesis, are present in regular diet fed-ob/ob mice but absent in the KD-fed mice

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The charged nature of GSH (negative at physiological pH) suggests that GSH cannot passively diffuse into the mitochondria, because the mitochondrial matrix has a negative potential relative to the cytoplasm