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its central effects begin with a few minutes, and last up to 4 hours (longer than fentanyl) distribution half life 1-6 mins

generally avoided Concurrent use with other potent neuroactive compounds: manage carefully Recommended precautions Always begin under physician supervision with a full medical history review Start at the lowest effective dose and titrate slowly Use cycling protocols avoid indefinite continuous use Monitor for neurological overstimulation symptoms Regular follow-up consultations during active protocols Who may be a candidate for Dihexa therapy