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Modulation of Axonal Transport Given that GDAP1 participates in mitochondrial axonal transport, small molecules that stabilize microtubule-dependent transport may restore organelle distribution and axonal integrity
Metformin has been explored as an adjuvant therapy for HCC, as low doses promote hepatoma cell senescence by activating the AMPK pathway and inhibiting SIRT1, offering a strategy to reduce tumor growth (Yi et al., 2013
The mean dose was 384 mg/day
