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BV biofilms are often resistant to antibiotics and can recur due to the existence of persister cells that have decreased metabolic activity and the physical barrier the biofilms create blocking antibiotics from accessing microbes within the extracellular polymeric substances, among other mechanisms 15,22,23

[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)

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NAFLD progression seems to involve the occurrence of parallel, multiple-hit injuries, such as oxidative stress-induced mitochondrial dysfunction, endoplasmic reticulum stress, endotoxin-induced, TLR4-dependent release of inflammatory cytokines, and iron overload, among many others
