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Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]

34 HuangS.RaoG.AshrafU.HeL.ZhangZ.ZhangH.et al (2020)

Mothers Set the Biochemical Tone of the Family From womb to weaning, and through the first years of life, the child is biologically tethered to the mother: Breastmilk carries methyl donors, immune signals, and inflammatory or anti-inflammatory mediators (Godfrey, 2011)
Interestingly, individuals with DM1 exhibit lower plasma concentrations and decreased activity of A1AT compared to other people (107)