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The timeline depends primarily on whether you were taking a short-acting or long-acting opioid, and how long you were taking it

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However, Que was also found to have potentially toxic effects including mutagenicity, pro-oxidant activity, mitochondrial toxicity, and inhibition of enzymes involved in hormonal metabolism ( Oxidative stress occurs following an imbalance of the bodys antioxidant defence mechanisms and excessive generation of free radicals, and is involved in various pathologies such as diabetes, atherosclerosis, hypertension, neurodegenerative diseases, inflammation, and cancer ( Que can also act as both an antioxidant and pro-oxidant agent