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Although the human colonic microflora is able to produce cobalamin, this synthesis takes place outside the place where vitamin B12 is absorbed from the digestive tract

This continues a series of annual editorial features dedicated to clinical research: in 2025 , Angelini Pharma produced an animated video infographic walking through the key steps and professional roles involved in a clinical trial, and in 2024 published an in-depth overview of how clinical trials work from the four development phases to the role of regulatory authorities

Thus, scientists must note that unanticipated reactions may emerge as research progresses

doi: 10.14309/ajg.0000000000001795