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M.LeoM.deC.SantanaT
SIRT3, SIRT4, and SIRT5 are mitochondrial and can shuttle to the nucleus ( The enzymatic activity of SIRTs is dependent on NAD + as a cofactor and plays an important role in controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis
Howe GA, Schilmiller AL
Karki et al., 2014
