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In human colon cancer cells, silencing NNMT resulted in approximately a 30% increase in NAD + levels (Xie et al., 2014), whereas NNMT overexpression decreased NAD + levels by 30% (Xie et al., 2014)
A portion of the iron in the cytoplasm is transported to the mitochondria for the synthesis of heme and iron-sulfur clusters (ISCs) [72]
A dossier has been submitted for EFSA evaluation
