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Moreover, ferroptosis may influence the epithelial-mesenchymal transition (EMT) process in tumor cells, thus enhancing the invasiveness and metastatic potential of lung cancer cells (74)
This outcome might be linked to the triggering of F-actin formation, as indicated by FITC-phalloidin staining
Maher JM, Cheng X, Slitt AL, Dieter MZ, Klaassen CD
Decreased activity of the mitochondrial respiratory chain was reported in overweight/obese patients with NASH compared to controls [97, 98], and alterations in mitochondrial ultrastructure have been observed prior to NAFLD development in the Otsuka LongEvans Tokushima Fatty rat [99] as well as in patients with steatosis preceding progression to NASH [100]
