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doi: 10.1126/science.8259521 23 DermanA

AONs are readily available through solid-phase oligonucleotide synthesis and therefore represent an ideal starting point for most oligonucleotide conjugations
The inhibition of GAPDH by thiol reagents such as iodoacetamide, p -chloromecuribenzoate and N -ethylmaleimide pointed to involvement of an active-site sulfhydryl residue
