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All MD simulations were performed with the program package GROMACS (version 2020.4) 32 using the GROMOS 54a7 force field 33

Acknowledgements We sincerely thank Ya-Hui Tsai, PhD, research specialist in the Division of Pediatric Surgery, Department of Surgery, Far-Eastern Memorial Hospital for editing the figures in the manuscript

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UA and MS MS is a chronic demyelinating neurodegenerative disease of unknown etiology [155]