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The driver may be mast-cell-mediated or systemic rather than NF-B-local, so dose escalation will not reach it see the mast-cell note under Phenotype Considerations

doi: 10.1016/j.tube.2018.12.007 151 RaoMValentiniDZumlaAMaeurerM
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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Chen J.G., Kensler T.W., Zhu J., Zhu Y.R., Wang J.B., Lu J.H., Muoz A., Groopman J.D
