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DME was removed under reduced pressure, the remaining residue adjusted to pH 2 with aqueous 1 M HCl and extracted 3-times with ethyl acetate (EtOAc)

Overall, our studies demonstrate how natural products, computation, and chemoproteomic profiling can augment electrophile design, providing a foundation for inhibitor discovery and optimization

Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity