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Cytokines are small soluble proteins that act as signaling molecules in the immune system

Reducing the dose to 3 mg daily or administering earlier in the evening rather than at bedtime may help

57,81,84 This close connection between the gut and the brain has been described as the gut-brain axis, and the gut microbiome and gut-associated neurons have been referred to as the second-brain. 85 5 Diagnosis Diagnosing anxiety disorders involves screening through careful history-taking, ruling out other causes of anxious symptoms, and use of diagnostic surveys